2,3,3,4,4-pentafluoro-5-methoxy-2,5-bis[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]tetrahydrofuran

Surface tension

Administrative data

Endpoint:

surface tension

Data waiving:

other justification

Justification for data waiving:

the study does not need to be conducted because water solubility is below 1 mg/L at 20°C

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2013-01-04 to 2013-02-01

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Name of substance as used in the study: L-21343
- Source and lot/batch No.of test material: 161255-76
- Purity: 99.87% sum of (2) isomers
- Expiration date of the lot/batch:9/24/2014

Key result

Water solubility:

0.407 µg/L

Conc. based on:

test mat.

Incubation duration:

>= 3 - <= 13 d

Temp.:

22.6 °C

Remarks on result:

other: pH not reported

Details on results:

Average measured NOVEC 7700 water solubility in individual vials ranged from 0.210 ng/mL to 0.958 ng/mL. The intra-day average solubility concentration ranged from 0.233 ng/mL to 0.568 ng/mL. The overall average (N=9) was 0.407 ng/mL (RSD = 28%).

Table 1. Summary of NOVEC 7700 water solubility results (ng/mL) 

Time point	Incubation time interval	Average vial 1 conc. ^(1) (ng/mL)	Average vial 2 conc. ^(1) (ng/mL)	Average vial 3 conc. ^(1) (ng/mL)	Average intra-day conc. (ng/mL)	intra-day %RSD	N
1	3 days	0.333	0.310	0.360	0.334	7.1	9
2	4 days	0.388	4.81^(2)	0.294	0.341^(3)	16	6 ^(2)
3	5 days	0.281	0.384	0.345	0.337	14	9
4	6 days	0.417	0.468	0.821	0.568	34	9
5	10 days	0.857	0.302	0.348	0.502	55	9
6	6 days	0.249	0.407	0.388	0.348	22	9
7	8 days	0.353	0.453	0.545	0.450	19	9
8	10 days	0.210	0.222	0.267	0.233	12	9
9	13 days	0.958	0.279	0.414	0.550 ^(3)	63	9
Inter-day Average					0.407 ^(4)	28	9

(1)   Average of triplicate measurements

(2)   Statistical outliers, data excluded from the intra-day average and RSD%;

(3)   Laboratory matrix spike recovery < 70%;

(4)   Inter-day average calculated using the nine intra-day averages.

Conclusions:

Under the conditions of the study, the average measured water solubility of NOVEC 7700 is 0.407 µg/L (RSD = 28%).

Executive summary:

The water solubility of NOVEC 7700 was determined according to the U.S. EPA guidance document OPPTS 830.7840 “Water Solubility: Column Elution Method; Shake Flask Method”.

Triplicate samples were prepared by injecting 100 µl of NONEV 7700 into the test vials pre-filled with Milli Q reagent water to zero-headspace. The vials were incubated at approximately 30°C with shaking at 100 rpm for total of nine time points: The initial 5 time points (3, 4, 5, 6 and 10 days), and additional second 4 time points (6, 8, 10 and 13 days). Time intervals for the second sample preparation were selected to overlap the previous time points. At the end of each time point, the vials were centrifuged at a setting of 1500 rpm for 60 minutes, then allowed to equilibrate for at least 24 hour. Triplicate aliquot of 5 mL of the aqueous solution were removed from the test vial and transferred to a separate vial containing 5 mL of MilliQ water, and analyzed using purge and trap gas chromatography/mass spectrometry (GC/MS).The intra-day average solubility concentration ranged from 0.233 ng/mL to 0.568 ng/mL. The overall average (N=9) was 0.407 ng/mL (RSD = 28%).

This is a guideline study conducted under GLP. Therefore, it is considered reliable without restriction and a key study.