1-bromooctadecane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Remarks:

Single oral administration

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 December 1993 to 4 July 1994

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1994

Report date:

1994

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

Version 1987

Deviations:

yes

Remarks:

The test article is a white solid at room temperature and a colorless liquid at 30°C The test article was administered after heating at 30°C The body weight of three females were noted beyond the norms (120 to 180 g): from 114 to 117 g

GLP compliance:

yes

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-bromooctadecane

EC Number:

204-013-4

EC Name:

1-bromooctadecane

Cas Number:

112-89-0

Molecular formula:

C18H37Br

IUPAC Name:

1-bromooctadecane

Test material form:

liquid

Details on test material:

The substance need to be melted before administration

Specific details on test material used for the study:

Stearyl bromide, white solid, batch number:9309005, packaging: glass container, storage at room temperature

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

5 males and 5 females
Adult 5 to 7 weeks old
Housing: in an air-conditionning building, temperatue: 19to 25°C, relative humidity: 30 to 70%, airchanges:minimum 8 air changes per hour, lighting cycle: 12 hours light (artificial)/12 hours dark

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2009 mg/kg

No. of animals per sex per dose:

All the animals received the same dose

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 009 mg/kg bw

Based on:

test mat.

Mortality:

No mortality was observed

Clinical signs:

There were no changes in behaviour or clinical signs in any of the treated animals during the observation period

Body weight:

Body weight changes in the treated animals were not influenced by treatment

Gross pathology:

There were no macroscopic findings that could be associated with treatment

Applicant's summary and conclusion

Interpretation of results:

Category 1 based on GHS criteria

Conclusions:

From the results obtained under the experimentals conditions employed, the LD50 can be expressed as follow:
LD50, by the oral route, in the rat (male + female) > 2009 mg/kg

Executive summary:

LD50, by the oral route, in the rat (male + female) > 2009 mg/kg