Registration Dossier
Registration Dossier
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EC number: 229-755-6 | CAS number: 6707-60-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Testing was performed before OECD guideline published.
- GLP compliance:
- no
Test material
- Reference substance name:
- 12-oxahexadecan-16-olide
- EC Number:
- 229-755-6
- EC Name:
- 12-oxahexadecan-16-olide
- Cas Number:
- 6707-60-4
- Molecular formula:
- C15H28O3
- IUPAC Name:
- 1,6-dioxacycloheptadecan-7-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- name of testing material: 77-227 Hibiscolide
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
- Preliminary study:
- Acute oral toxicity in rates
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 10 rats were used in the study. The animals were observed over a 14 day period for mortality and/or systemic effects. A gross necropsy was conducted on all animals.
The oral LD50 of 12-oxahexadecanolide in rats exceeded 5000 mg/kg with 0/10 deaths at that dose - Executive summary:
The oral LD50 of 12-oxahexadecanolide in rats exceeded 5000 mg/kg with 0/10 deaths at that dose.
Cevolide does not met the criteria for classication according the CLP Regulation (EC) No. 1272/2008.
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