Benzenesulfonic acid, mono-C10-13-alkyl derivs., potassium salts

Endpoint summary

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Skin irritation - in vivo:

A study was conducted to determine the skin irritation / corrosion potential of the read-across substance, benzenesulfonic acid, C10-13-alkyl derivs., sodium salts,

according to OECD Guideline 404. Clipped skin of three rabbits was exposed to 0.5 mL of the test substance for 4 h. The test substance was covered with an occlusive dressing and removed by washing 4 h later. Animals were examined at 30 min after removal of the dressing, and daily thereafter for 14 d. Grading and scoring of the dermal reactions were performed using the standard numerical scoring system. Irritation was noted in all animals at the first observation (score of 2). Symptoms worsened, and desquamation, necrosis, and hyperkeratinization were noted by Day 4. Symptoms resolved in one animal by Day 12, but in the other two animals, symptoms were observed throughout the study. The primary dermal irritation index was determined to be 2.17. Under the study conditions, the substance was considered to be irritating to rabbit skin (Liggett, 1986a).

Eye irritation - in vivo:

A study was conducted to determine the eye irritation potential of the read-across substance, benzenesulfonic acid, C10-13-alkyl derivs., sodium salts,

according to OECD Guideline 405, in compliance with GLP. A set of three studies were performed. 0.1 mL of the undiluted test substance was placed into the eyes of groups of three rabbits. In one group, the eyes were not rinsed. In the second group, the eyes were rinsed after 4 sec of exposure and in the third group, the eyes were rinsed after 30 sec of exposure. Observations were made at 1 h and 1, 2, 3, 4, 7, 14, and 21 d after exposure. Severe irritation was noted in the animals whose eyes were not rinsed. This irritation was not resolved in one of these animals at the end of 21 d. Irritation was also seen in the animals rinsed after 30 sec, although the irritation was not as severe, and the effects were fully reversible within 14 d. Mild irritation was seen in the animals rinsed after 4 sec. These effects were fully reversible within 7 d. Under the study conditions, the substance was considered to be damaging to eyes (Liggett, 1986b).

Justification for classification or non-classification

Based on the results of in vivo studies with the read-across substance, benzenesulfonic acid, C10-13-alkyl derivs., sodium salts in rabbits, the substance warrants a classification as Skin Irrit. Cat 2 - H315 (causes skin irritation) and Eye Damage 1 - H318 (causes serious eye damage) according to EU CLP (EC 1272/2008) criteria.