Registration Dossier
Registration Dossier
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EC number: 201-732-5 | CAS number: 87-22-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from a peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study using the test chemical
- Author:
- A. Lapczynski et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology (2007)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Equivalent or similar to OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phenethyl salicylate
- EC Number:
- 201-732-5
- EC Name:
- Phenethyl salicylate
- Cas Number:
- 87-22-9
- Molecular formula:
- C15H14O3
- IUPAC Name:
- phenethyl salicylate
- Test material form:
- solid
- Details on test material:
- Name: Phenethyl salicylate
Molecular Formula: C15H14O3
Molecular Weight: 242.2726 g/mol
SMILES: c1ccc(cc1)CCOC(=O)c2ccccc2O
Substance Type: Organic
Physical State: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data Available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Nine rabbits received a single dermal application of neat test chemicals at a dose of 5 g/kg.
- Duration of exposure:
- Single exposure (24 hours)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 9 rabbits were used in this study.
- Control animals:
- not required
- Details on study design:
- No Data Available
- Statistics:
- No Data Available
Results and discussion
- Preliminary study:
- No Data Available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at any given doses.
- Clinical signs:
- other: No clinical sgns were observed at the tested doses.
- Gross pathology:
- No Data Available
- Other findings:
- No Data Available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- No clinical signs or mortality were observed. Thus, based on all the observations and results, it was concluded that the LD50 of the test chemical was observed to be >5000 mg/kg bw.
- Executive summary:
An acute dermal toxicity study was performed to evaluate the toxic potential of the test chemical in rabbits.Nine rabbits received a single dermal application of neat test chemical at a dose of 5 g/kg. The rabbits were observed for mortality and/or systemic effects for 14 days. No clinical signs or mortality were observed. Thus, based on all the observations and results, it was concluded that the LD50 of the test chemical was observed to be >5000 mg/kg bw.
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