Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
Reaction mass of bis(polysubstituted hexanoic acid) bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) diphosphate and bis(polysubstituted hexanoic acid) 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl phosphate and polysubstituted hexanoic acid bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrogen diphosphate and polysubstituted hexanoic acid bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) phosphate and polysubstituted hexanoic acid 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl hydrogen phosphate
EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
The mean viability of the test
substance was evaluated in a Skin Irritation Test using the EpiDerm™
Skin Model. The test substance, positive control, and
negative control were exposed to the EpiDerm™ tissues in triplicate for
60 minutes, with a post-exposure time of 42 hours. Irritation potential
was determined by measuring the relative conversion of MTT (3-[4,5 -
dimethylthiazol-2-yl] - 2,5 - diphenyltetrazolium bromide) in the test
substance-treated tissues after exposure to the test substance for a
60-minute exposure period, followed by a 42-hour post-exposure
expression period. Skin irritation potential of the test substance was
predicted if the relative viability was less than or equal to 50%. The
mean viability of the test substance was 102.4%. The test substance was
not determined to directly reduce MTT. Based upon the results of this
assay, the test substance was not predicted to be a skin irritant.
The Bovine Corneal Opacity and Permeability Assay was used to assess the
potential ocular irritancy of the test substance as measured by changes
in opacity and permeability (to fluorescein) in isolated bovine corneas.
Based on changes in corneal opacity and permeability (relative to the
control corneas), an in vitro score was determined. The in vitro score
was 1.7. Following the classification established by Gautheron et al.
(1992) (Sina classification system) based on studies with a wide range
of test materials, the test substance, would be considered a mild
irritant (in vitro score from 0 to 25). Following the modification of
the Sina classification system proposed by Vanparys, et al. (1993) based
on an evaluation of 50 pharmaceutical and commercially-available
industrial compounds, the test substance would be considered a
non-irritant (an vitro score from 0 to 3).
Therefore, the substance does not need to be classified for skin or eye
irritation according the EU Directive 67/548/EEC and EU Classification,
Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC)
No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
