Registration Dossier
Registration Dossier
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EC number: 202-185-5 | CAS number: 92-74-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Full detailed report, GLP,
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 3-Hydroxy-N-(2-ethoxyphenyl)-2-naphtalincarboxamid
- IUPAC Name:
- 3-Hydroxy-N-(2-ethoxyphenyl)-2-naphtalincarboxamid
- Reference substance name:
- Naphtol AS-PH
- IUPAC Name:
- Naphtol AS-PH
- Reference substance name:
- 2'-ethoxy-3-hydroxy-2-naphthanilide
- EC Number:
- 202-185-5
- EC Name:
- 2'-ethoxy-3-hydroxy-2-naphthanilide
- Cas Number:
- 92-74-0
- Molecular formula:
- C19H17NO3
- IUPAC Name:
- N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide
Constituent 1
Constituent 2
Constituent 3
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver S9-mix
- Test concentrations with justification for top dose:
- 0.8 - 5000 µg/Platte in DMSO
Results and discussion
Test results
- Species / strain:
- other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538 and Escherichia coli WP2uvrA
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with and without metabolic activation
Naphtol AS-PH FWTR was not mutagenic in the presence and absence of a metabolizing system in Slamonella typhimurium and Escherichia coli.
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