Registration Dossier
Registration Dossier
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EC number: 441-570-4 | CAS number: -
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out : Reaction mass of Di-μ-thio-[{bis(2-ethylhexyl)carbamato-S,S’}oxo molybdenum(V)], Di-μ-thio-[{(2-ethylhexyl)carbamato-S,S’}{(branched ditridecyl)carbamato-S,S’}oxo molybdenum(V)] and Di-μ-thio-[{bis(branched ditridecyl)carbamato-S,S’}oxo molybdenum(V)]
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies : OECD 421, OECD 407
- Available non-GLP studies : none
- Historical human data : none
- (Q)SAR : none
- In vitro methods : no method available
- Weight of evidence : not sufficient data
- Grouping and read-across : not sufficient data
- Substance-tailored exposure driven testing [if applicable] : not applicable
- Approaches in addition to above [if applicable] : not applicable
- Other reasons [if applicable] : none
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
The substance did not exhibit significant toxicity in the available mammalian studies. However, the effect on body weight development in the OECD 421 study indicates that the substance could be systemically available after oral dosing. Therefore, performance of the OECD 414 study is proposed according to the REACH Regulation Annex IX.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed [if relevant]
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Version / remarks:
- 2018
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 441-570-4
- EC Name:
- -
- Molecular formula:
- C34 H68 Mo2 N2 O2 S6 C44 H88 Mo2 N2 O2 S6 C54 H108 Mo2 N2 O2 S6
- IUPAC Name:
- hexamolybdenum(3+) tris((dioctylcarbamothioyl)sulfanide) tris((ditridecylcarbamothioyl)sulfanide) hexahydrate hexasulfanediide
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
