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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Biodegradation in water

Biodegradability of N-(4-sulfamoylphenyl)acetamide (CAS no. 121 -61 -9) is predicted using OECD QSAR toolbox version 3.4 (2017) with logKow as the primary descriptor. Test substance undergoes 5.6% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical N-(4-sulfamoylphenyl)acetamide was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-(4-sulfamoylphenyl)acetamide (CAS No. 121 -61 -9). If released in to the environment, 33.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of N-(4 -sulfamoylphenyl) acetamide in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-(4-sulfamoylphenyl)acetamide in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0832%), indicates that N-(4-sulfamoylphenyl)acetamide is not persistent in sediment.

 

Biodegradation in soil

The half-life period of N-(4-sulfamoylphenyl)acetamide (CAS No. 121 -61 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 66.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-(4-sulfamoylphenyl)acetamide in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-(4-sulfamoylphenyl)acetamide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Various predicted data for the target compound N-(4-sulfamoylphenyl)acetamide (CAS No. 121-61-9) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemicalN-(4-sulfamoylphenyl)acetamide(CAS No. 121-61-9) was estimated. Test substance undergoes 5.6% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical N-(4-sulfamoylphenyl)acetamide was estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compoundN-(4-sulfamoylphenyl)acetamide(CAS No. 121-61-9) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical N-(4-sulfamoylphenyl)acetamide is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from peer reviewed journal (George W. Malaney, 1960) and authoritative databases (HSDB and SRC (Syracuse Research Corporation) PhysProp Database, 2017) for the read across chemical 4-aminobenzene-1-sulfonamide (CAS no. 63-74-1), biodegradation experiment was conducted for evaluating the percentage biodegradability of read across substance 4-aminobenzene-1-sulfonamide. Aniline-acclimated sludge was used as a test inoculum. The original source of microorganisms was mixed liquor from the aeration tank of a municipal treatment plant. Biodegradation of test chemical was tested by the conventional Warburg technique, using 125 ml flasks. Concentration of inoculum i.e, sludge used was 2,500 mg/l and initial test substance conc. used in the study was 500 mg/l. Incubation of the test vessel was carried out at 20ᵒC for 5-8 days i.e, 120-192 hrs. Oxidation in the test flask was recorded as mg O2 uptake per liter of the mixture in the flask. The mg of O2 uptake by the substance 4-aminobenzene-1-sulfonamide was determined to be 150 mg/l and the percentage degradation of substance 4-aminobenzene-1-sulfonamide was determined to be 0% by BOD parameter in 8 days. Thus, based on percentage degradation, 4-aminobenzene-1-sulfonamide is considered to be not readily biodegradable in nature.

 

Another biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance Benzene sulphonamide (CAS no. 98-10-2) (J-CHECK, 2017 and EnviChem, 2014). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance Benzene sulphonamide was determined to be 0, 3 and 1% by BOD, TOC removal and UV-Vis parameter in 14 days. Thus, based on percentage degradation, Benzene sulphonamide is considered to be not readily biodegradable in nature.

 

In a supporting weight of evidence study from authoritative database (HSDB, 2017) for read across substance4-Amino-N-(-5-methyl-3-isoxazolyl)benzenesulfonamide (CAS no. 723-46-6), bodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 4-Amino-N-(-5-methyl-3-isoxazolyl)benzene sulfonamide. The study was performed according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test) under aerobic conditions. Sewage was used as a test inoculum obtained from municipal treatment plant. The percentage degradation of substance 4-Amino-N-(-5-methyl-3-isoxazolyl)benzenesulfonamide was determined to be 2 and 4% by ThOD parameter in 14 and 28 day, respectively. Thus, based on percentage degradation, 4-Amino-N-(-5-methyl-3-isoxazolyl)benzenesulfonamide is considered to be not readily biodegradable in nature.

 

For the sameread across substance4-methylbenzene-1-sulfonamide (CAS no. 70-55-3) from secondary source (OECD SIDS, 1993) and authoritative database (GSBL database, 2017), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 4-methylbenzene-1-sulfonamide (CAS no. 70-55-3). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) under aerobic conditions at a temperature of 25°C. Activated sludge was used as a test inoculum. Conc. of inoculum and initial test substance conc. used was 30 and 100 mg/l, respectively. The percentage degradation of substance 4-methylbenzene-1-sulfonamide was determined to be 1, 4 and 3% by BOD parameter in 7, 14 and 28 days, respectively and 0% by DOC removal and HPLC in 28 days. Thus, based on percentage degradation, 4-methylbenzene-1-sulfonamide is considered to be not readily biodegradable in nature.

 

On the basis of above results for target chemical N-(4-sulfamoylphenyl)acetamide (from OECD QSAR toolbox version 3.4 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, HSDB, GSBL, EnviChem, peer reviewed journal and secondary source OECD SIDS), it can be concluded that the test substance N-(4-sulfamoylphenyl)acetamide can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-(4-sulfamoylphenyl)acetamide (CAS No. 121 -61 -9). If released in to the environment, 33.4% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of N-(4 -sulfamoylphenyl) acetamide in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-(4-sulfamoylphenyl)acetamide in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0832%), indicates that N-(4-sulfamoylphenyl)acetamide is not persistent in sediment.

 

Biodegradation in soil

The half-life period of N-(4-sulfamoylphenyl)acetamide (CAS No. 121 -61 -9) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 66.5% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-(4-sulfamoylphenyl)acetamide in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-(4-sulfamoylphenyl)acetamide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance N-(4 -sulfamoylphenyl)acetamide can be considered to be not readily biodegradable in nature.