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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
EC Number:
250-078-7
EC Name:
4-(tricyclo[5.2.1.02,6]dec-8-ylidene)butyraldehyde
Cas Number:
30168-23-1
Molecular formula:
C14H20O
IUPAC Name:
4-[(8Z)-tricyclo[5.2.1.0^{2,6}]decan-8-ylidene]butanal
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
Housed 5 per cage. Fresh purine rat chow and water were freely available except for 16-20 hours prior to dosing.
Room temperature controlled in accordance with AAALAC.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
Oral gavage by syringe and dosing needle.
Doses:
Dose 5 g/kg.
No. of animals per sex per dose:
10 male rats.
Control animals:
no
Details on study design:
One group of male rats were dosed at 5 g/kg bw.
The rats were observed at 3-4 hours post dose and daily for 14 days.
On day 14 all surviving rats were sacrificed and examined.

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
3 rats died out of 10 rats.
Clinical signs:
other: Some signs of piloerection, ptosis, coma, lethargy. All surviving animals were normal after 6 days.
Gross pathology:
The 3 rats that died showed signs of nose/mouth brown staining, anogenital brown staining, congested and haemorrhagic lungs, dilated heart, excess fluid in pleural cavity and distended stomach.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD 50: > 5.0 g/kg
Mortality : 3/10
Principle toxic signs: none
Necropsy: survivors - normal ; deaths - lung, heart, stomach and intestinal abnormalities
Executive summary:

LD 50: > 5.0 g/kg

Mortality : 3/10

Principle toxic signs: none

Necropsy: survivors - normal ; deaths - lung, heart, stomach and intestinal abnormalities

Dupical is non-toxic after oral administration.