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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report date:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexylamine
EC Number:
203-233-8
EC Name:
2-ethylhexylamine
Cas Number:
104-75-6
Molecular formula:
C8H19N
IUPAC Name:
2-ethylhexylamine

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gassner
- Weight at study initiation: 130-200 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 2.0, 4.0 8.0 and 20 % aqueous solution containing Traganth
Doses:
200, 400, 800, 1600 µl/kg bw = 158, 316, 632 and 1264 mg/kg bw; conversion into mg/kg is based on the density d= 0.79g/cm3 according to BASF internal data
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of application and daily thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
316 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 400 cm³/kg bw; calculated with a density of 0.79 g/cm³
Mortality:
1264 mg/kg bw dosing group: 20/20 within 1 hour
632 mg/kg bw dosing group: 20/20 within 1 hour
316 mg/kg bw dosing group: 10/20 within 1 hour
158 mg/kg bw dosing group: 0/20
Clinical signs:
200 cm³/kg bw dosing group:
strongly elevated respiration, anancasm to chew, slight salivation, slight tremor (females), fitful breathing on day 1, free of symptoms on day 2

400-800 cm³/kg bw dosing group:
strong anancasm to roll, strong twitches, dyspnoea, salivation, on day 3 without findings

1600 cm³/kg bw dosing group:
salaam convulsions, Tremor, extension convulsions, salivation, foreleg movements
Body weight:
no data
Gross pathology:
Died animals: Kidney obstructions, red-pink coloring of the stomach
Sacrificed animals: without findings

Any other information on results incl. tables

The test substance caused systemic toxicity (including mortality) in a dose dependent manner.

Mortality

 Dose (µL (kg)  Conc. (%)  No. of animals  died within  1 hour 24 hours 48 hours 7 days
 1600  20  20  20/20  20/20  20/20  20/20
 800  8  20  20/20  20/20  20/20  20/20
 400  4  20  10/20  10/20  10/20  10/20
 200  2  20  0/20  0/20  0/20  0/20

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria