2,6,8-trimethylnonan-4-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

circa 1949

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1949

Report date:

1949

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Groups of rats were exposed to a saturated vapor for 8 hours or to an aerosol for up to 8 hours. Animals were observed for 14 days following exposure. Animals that died were subjected to a gross necropsy.

GLP compliance:

no

Test type:

other: Range finding study

Test material

Test material information

Constituent 1

Reference substance name:

2,6,8-trimethylnonan-4-ol

EC Number:

204-606-8

EC Name:

2,6,8-trimethylnonan-4-ol

Cas Number:

123-17-1

Molecular formula:

C12H26O

IUPAC Name:

2,6,8-trimethylnonan-4-ol

Details on test material:

- Name of test material (as cited in study report): 2,6,8-Trimethyl Nonanol

Test animals

Species:

rat

Strain:

other: Not specified, however, Sherman strain were used in other sections of same report

Sex:

not specified

Administration / exposure

Route of administration:

other: vapor or condensation aerosol

Type of inhalation exposure:

other: Not specifically stated but expected to be whole-body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

2 - 8 h

Concentrations:

Rats were exposed to a substantially saturated vapor generated at room temperature or to a mist generated by aerating the compound while held in a bath at 170C

No. of animals per sex per dose:

6 rats for vapor study

6 rats for 2, 4 or 8 hour exposure

Control animals:

not specified

Results and discussion

Any other information on results incl. tables

All rats survived the 8 hour exposure to a substantially saturated vapor. Body weight gains were described as good.

A mist prepared by aerating the compound while held in a bath at 170C was lethal to 6 of 6 rats in 8 hours, 3 of 6 hours and 0 of 6 in 2 hours. Respiratory distress and poor coordination were noted after the rats had been exposed for about 1 1/2 hours. Deaths were probably caused by irritant action on the lung as necropsy revealed hemorrhage of this organ.

Applicant's summary and conclusion

Conclusions:

Based on the results of the study, saturated vapor at room temperature does not constitute a hazard to rats in 8 hour exposures.

Executive summary:

The acute inhalation toxicity of trimethyl nonanol was examined. All rats survived an 8 hour exposure to a saturated vapor of trimethyl nonanol.

Half of the rats survived a 4 hour exposure to an aerosol prepared by passing air through heated material. Stability of the test material at this temperature was not stated in the report. Nor was the concentration determined.