Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1977

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Ten volunteers received dermal patches with several substances for two weeks, followed by one week without treatment and than one challenge treatment
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminophenol
EC Number:
202-431-1
EC Name:
2-aminophenol
Cas Number:
95-55-6
Molecular formula:
C6H7NO
IUPAC Name:
2-aminophenol
Test material form:
solid
Specific details on test material used for the study:
none

Method

Type of population:
not specified
Ethical approval:
not specified
Subjects:
unknown
Route of administration:
dermal
Details on study design:
Dermal application was done between April 25, 1977 and June 23rd 1977

Results and discussion

Results of examinations:
One of 10 volunteers developed an allergy to 1-Hydroxy-2-Aminobenzol

Applicant's summary and conclusion