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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-α,α,α-trifluorotoluene
EC Number:
202-642-9
EC Name:
3-chloro-α,α,α-trifluorotoluene
Cas Number:
98-15-7
Molecular formula:
C7H4ClF3
IUPAC Name:
1-chloro-3-(trifluoromethyl)benzene
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Strain: Hoe: WISKf (SPF71)
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: males: 189 g - 196 g (average 192 g); females: 186 g - 193 g (average 189 g)
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 50 +/- 20%
- Photoperiod: 12 hrs dark / 12 hrs light

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Remarks:
Gas chromatography with external standard
Duration of exposure:
4 h
Concentrations:
23,6 mg/L
No. of animals per sex per dose:
5 animals per sex per dose in the treatment groups
Control animals:
no
Details on study design:
- Duration of observation period following administration: all animals 14 days
exposure 21 days
- Frequency of observations: exact observation during inhalation period
- Frequency of weighing: before exposure, day 7 and 14 post exposure
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 23.6 mg/m³ air (analytical)
Based on:
act. ingr.
Exp. duration:
4 h
Mortality:
No animals died during exposure or post exposure period
Clinical signs:
other: Besides to nonspecific symptoms, the animals showed impairments of movement and breathing. In addition, trembling, decreased control reflex, drowsiness and anesthesia were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the results of this study the 4h LC50 of 3-Chlorobenzotrichloride is greater than 23.6 mg/L.