Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 500 mg/L
- EC10 or NOEC for freshwater algae:
- 500 mg/L
Additional information
No experimental results are available for L-methionine.
The toxic effect of D,L-methionine was assessed in a static growth inhibition test (2002-0518-DGO) with green algae Desmodesmus subspicatus according to OECD 201. The EC50 and NOEC value after 72 h was determined as >1000 mg/l D,L-methionine, demonstrating that even 1000 mg/l D,L-methionine has no toxic effect on aquatic algae.
Read-across of D,L-methionine study to L-methionine was used due to structural similarities and the physico-chemical similarities according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%). Taking this into account it can be concluded that the EC50 and NOEC of L-methionine is > 500 mg/l as a worst case approach.
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