Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
L-Methionine is readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The only biodegradation study available for L-methionine was insufficiently documented and no guideline was followed (81 -0280 -DKO).
The key study (2001 -0078 -DGO) performed with D,L-methionine in accordance to GLP and guideline OECD 301 A showed a degree of 97% degradation within 28 days. 10 days after which the biodegradation has reached 10%, D,L-methionine was degraded by >70%, due to this D,L-methionine was considered to be readily biodegradable.
Other read across publications support the biodegradability of D,L-methionine. Two studies resulted in a slow oxidation of D,L-methionine or concluded that the test culture was still undergoing acclimation (Malaney and Gerhold 1969; Engelbrecht and Mc Kinney 1957). A test in a Warburg manometer (Dawson et al. 1950) showed an increase in oxygen uptake and D,L-methionine was also biodegradable under anaerobic conditions as shown by Stuckey and McCarty (1984).
Overall, D,L-methionine is confirmed as readily biodegradable. This can also be concluded for L-methionine as this is the naturally omnipresent methionine enantiomer, a proteinogenic amino acid which also serves as carbon/energy source for bacterial/microbial growth.
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