Registration Dossier
Registration Dossier
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EC number: 202-169-8 | CAS number: 92-59-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice
- Author:
- E. W. Schafer, Jr. and W. A. Bowles, Jr.
- Year:
- 1 985
- Bibliographic source:
- Arch. Environ. Contain. Toxicol. 14, 111-129 (1985)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Acute oral toxicity study was performed to determine the single dose oral exposure of N-benzyl-N-ethylaniline to mice
- GLP compliance:
- not specified
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- N-benzyl-N-ethylaniline
- EC Number:
- 202-169-8
- EC Name:
- N-benzyl-N-ethylaniline
- Cas Number:
- 92-59-1
- Molecular formula:
- C15H17N
- IUPAC Name:
- N-benzyl-N-ethylaniline
- Details on test material:
- SMILES:CCN(Cc1ccccc1)c1ccccc1
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: N-benzyl-N-ethylaniline
- Molecular formula: C15H17N
- Molecular weight : 211.306 g/mol
- Smiles notation: N(c1ccccc1)(Cc1ccccc1)CC
- InChl: 1S/C15H17N/c1-2-16(15-11-7-4-8-12-15)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- other: House mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): 25 white wheat seed
ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Feed
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: White wheat seeds
- Amount of vehicle (if gavage): 25 seeds
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: No data
DOSAGE PREPARATION (if unusual): No data
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: No data - Doses:
- 2.0% wt/wt
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 5 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: No data
- Other examinations performed: other: The animals were observed for REP i.e Percentage of mice refusing to eat more than 50% of 2.0%-treated wheat - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: REP
- Remarks:
- Percentage of mice refusing to eat more than 50% of 2.0%-treated wheat
- Effect level:
- 2 other: %
- Based on:
- test mat.
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The repellency percentage for house mouse to Ethyl benzyl aniline (92-59-1) was considered to be 2.0 %.
- Executive summary:
Acute toxicity test was performed for Ethylbenzylaniline to 10 mice at 2% concentration during 5 day test of repellency. The animals were fed 25 white wheat seeds treated with 2.0% of the target chemical. The test results, designated as REP, were summarized by the percentage of mice refusing to eat an average of 13 or more treated seeds per day during the 5-day test period. The repellency percentage for house mouse to Ethyl benzyl aniline (92-59-1) was considered to be 2.0 %.
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