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Registration Dossier
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EC number: 453-460-3 | CAS number: -
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 November 2015 to 29 January 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Boiling pt.:
- ca. 277 °C
- Atm. press.:
- 101 kPa
- Remarks on result:
- other: Boiling temperature of the test item was determined to be from approximately 277 °C (550 K) at 101 kPa.
- Conclusions:
- Boiling temperature of the test item was determined to be from approximately 277 °C (550 K) at 101 kPa.
- Executive summary:
GUIDELINE
Boiling temperature was investigated by differential scanning calorimetry using a method designed to be compatible with Method A.2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
RESULTS
Boiling temperature of the test item was determined to be from approximately 277 °C (550 K) at 101 kPa.
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 06 November 2012 to 18 January 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Boiling pt.:
- > 400 °C
- Atm. press.:
- 101.5 kPa
- Decomposition:
- no
- Conclusions:
- The test item did not boil up to 400 °C (673 K) at 101.5 kPa by differential scanning calorimetry.
- Executive summary:
Method
The determination was carried out by differential scanning calorimetry (DSC) using a procedure designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Conclusion
The test item did not boil up to 400 °C (673 K) at 101.5 kPa by differential scanning calorimetry,
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- GLP compliance:
- yes
- Type of method:
- method according to Siwoloboff
- Boiling pt.:
- > 300 °C
- Atm. press.:
- 102.06 kPa
- Remarks on result:
- other: Test substance was stable under the conditions of the test.
- Endpoint:
- boiling point
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Boiling pt.:
- > 400 °C
- Atm. press.:
- 101.5 kPa
- Decomposition:
- no
- Conclusions:
- The test item did not boil up to 400 °C (673 K) at 101.5 kPa by differential scanning calorimetry.
- Executive summary:
Method
The determination was carried out by differential scanning calorimetry (DSC) using a procedure designed to be compatible with Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Conclusion
The test item did not boil up to 400 °C (673 K) at 101.5 kPa by differential scanning calorimetry,
- Endpoint:
- boiling point
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Boiling pt.:
- > 300 °C
- Atm. press.:
- 102.06 kPa
- Remarks on result:
- other: Test substance was stable under the conditions of the test.
Referenceopen allclose all
RESULTS
- Thermograms for Determinations 1 and 2 are shown in Figures 1 and 2 (attached).
- Thermographic data for Determinations 1 and 2 are given in Table 3 (below).
- After heating to 400 °C, the samples had lost approximately 13 % (Determination 1) and 14 % (Determination 2) of their original mass.
Table 3 – Thermographic data |
|||||
Thermal event |
Interpretation |
Temperature |
|||
Determination 1 |
Determination 2 |
||||
°C |
K |
°C |
K |
||
Endotherm |
Onset of boiling |
276.69 |
549.84 |
283.85 |
557.00 |
Overall result: boiling from approximately 277 °C (550 K) |
|||||
Atmospheric pressure 101 kPa |
|||||
Thermatographic data shown in the attached document
Approx. 3 minutes after the capillary containing the test substance was inserted into the oven at 305 °C, the plug of test substance moved less than approx. 5 mm in the capillary tube, and remained inside the oven (it did not migrate to a cooler region of the pipette outside the oven). The colour of the test substance did not change during the test, which was consistent with the test substance being thermally stable under the conditions of the test.
Thermatographic data shown in the attached document
Approx. 3 minutes after the capillary containing the test substance was inserted into the oven at 305 °C, the plug of test substance moved less than approx. 5 mm in the capillary tube, and remained inside the oven (it did not migrate to a cooler region of the pipette outside the oven). The colour of the test substance did not change during the test, which was consistent with the test substance being thermally stable under the conditions of the test.
Description of key information
Boiling temperature of the test item was determined to be from approximately 277 °C (550 K) at 101 kPa (OECD 103 and EU Method A.2).
Key value for chemical safety assessment
Additional information
GUIDELINE
Boiling temperature was investigated by differential scanning calorimetry using a method designed to be compatible with Method A.2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
RESULTS
Boiling temperature of the test item was determined to be from approximately 277 °C (550 K) at 101 kPa.
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