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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authorized database

Data source

Reference
Reference Type:
other: Authorized database
Title:
Acute oral toxicity of CAS no 57-13-6
Author:
U. S. National Library of Medicine
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC, 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of Urea in rats
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
Name of the test chemical: Urea
Molecular Weight: 60.0556 g/mol
Molecular Formula:CH4N2O
InChI: 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
Substance Type: Organic
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical: Urea
Molecular Weight: 60.0556 g/mol
Molecular Formula:CH4N2O
InChI: 1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
Substance Type: Organic
Physical State: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
8471 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
8 471 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
not specified
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 8471 mg/kg bw when rat were treated with Urea.
Executive summary:

In a acute oral toxicity study,rats were treated with Urea orally. 50 % mortality observed was observed in treated rats at 8471 mg/kg bw. Therefore,LD50 was considered to bemg/kg bw when rats were treated with Urea.