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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
Prediction done by ECOSAR v1.00 model.
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material: 1-(3-aminophenyl)urea
- Molecular formula: C7 H9 N3 O
- Molecular weight: 151.168 g/mol
- Smiles notation: O=C(Nc1cccc(N)c1)N
- InChl: 1S/C7H9N3O/c8-5-2-1-3-6(4-5)10-7(9)11/h1-4H,8H2,(H3,9,10,11)
- Substance type: Organic
- Physical state: Solid
Test organisms (species):
other: Fish
Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
37 434.19 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Validity criteria fulfilled:
not specified
Conclusions:
The lethal concentration LC50 value for the substance was estimated to be 37434.19 mg/l in fish for 96 hr duration. Based on this value it can be concluded that the 1-(3-aminophenyl)urea   (CAS:25711-72-2) is likely to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.
Executive summary:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance  1-(3-aminophenyl)urea (CAS:25711-72-2) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 37434.19 mg/l in fish for 96 hr duration. Based on this value it can be concluded that the 1-(3-aminophenyl)urea   (CAS:25711-72-2) is likely to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.

Description of key information

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance  1-(3-aminophenyl)urea (CAS:25711-72-2) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 37434.19 mg/l in fish for 96 hr duration. Based on this value it can be concluded that the 1-(3-aminophenyl)urea   (CAS:25711-72-2) is likely to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.

Key value for chemical safety assessment

LC50 for freshwater fish:
37 434.19 mg/L

Additional information

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance  1-(3-aminophenyl)urea (CAS:25711-72-2) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 37434.19 mg/l in fish for 96 hr duration. Based on this value it can be concluded that the 1-(3-aminophenyl)urea   (CAS:25711-72-2) is likely to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.