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EC number: 944-855-6
CAS number: 199445-85-7
A GLP study was performed folowing a method similar to
OECD 401 to assess the toxicity of the test item following oral
administration to Sprague-Dawley rats. The test item was administered as
a single dose to a group 5 males and 5 female rats at dose level of 2000
mg/kg bw, this is followed by 14 days observation period for any signs
of toxicity or any other effects of treatment. All animals were examined
for gross patholog, one female death noted on day two of treatment.
Piloerection and hyperactivity were noted in majority of the animals,
one male exhibited a hunched posture - all clinical signs subsided by
day 3. Necropsy findings were consitent with normal macroscopic
background pathathology. Under the conditions of this study the LD50 was
determined to be > 2000 mg/kg bw in male/female Sprague-Dawley rats.
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