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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Qualifier:
according to guideline
Guideline:
other: refer below principle
Principles of method if other than guideline:
QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis Using Topological Indices.
GLP compliance:
no
Specific details on test material used for the study:
- IUPAC name 2-methyl-4-nitroaniline
- Name of test material: 4-nitro-o-toluidine
- Molecular formula: C7H8N2O2
- Molecular weight: 152.152 g/mol
- Physical state: Solid
- SMILES: c1(cc(c(N)cc1)C)[N+](=O)[O-]
- InChI: 1S/C7H8N2O2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,8H2,1H3
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Tetrahymena pyriformis
Test type:
not specified
Water media type:
freshwater
Remarks on exposure duration:
not specified in study
Reference substance (positive control):
not specified
Key result
Dose descriptor:
other: IGC50
Effect conc.:
109.64 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l
Reported statistics and error estimates:
TOPOCLUJ software program
Validity criteria fulfilled:
not specified
Conclusions:
QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.
Executive summary:

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.This estimated IGC50 value suggest that chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) may not have toxicity concern to micro organism Tetrahymena pyriformis.

Description of key information

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:
109.64 mg/L

Additional information

QSTR Study on Aquatic Toxicity Against Tetrahymena pyriformis using Topological Indices for chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) indicate that the toxicity data as 50% growth inhibitory concentration (log 1/IGC50 = pIGC50) against micro organism species Tetrahymena pyriformis was estimate to be 1/log IGC50 =2.04 which is equivalent to 109.64 mg/l.This estimated IGC50 value suggest that chemical 2-methyl-4-nitroaniline (Cas no.99-52-5) may not have toxicity concern to micro organism Tetrahymena pyriformis.