Registration Dossier
Registration Dossier
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EC number: 202-809-6 | CAS number: 100-00-5
Endpoint summary
Administrative data
Description of key information
p-Chloronitrobenzene is considered not irritating to the skin and to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The skin irritation potential of 1 -chloro-4 -nitrobenzene was investigated in 6 New Zealand White rabbits. An 2.5 x 2.5 cm area of intact shaved animal skin and scarrified skin was used to applicate the test substance. Gauze pads were loaded with 500mg 1 -chloro-4-nitrobenzene suspended with 1 or 2 drops of water. The test areas were covered occlusive with a layer of PVC-film (5 x 5 cm) and adhesive tape (Leukoflex). The exposure duration was 24 hours. The reading times were 24, 48, 72 hours and 8 days after application. Day 8 post application was not included in the evaluation. The mean erythema scores at 24, 72 hours and 8 days were 0.0 in all animals in intact skin. The mean oedema score at the 24 hour reading point was 2.17 and at 72 hours 1.0. The mean scores do not justify classification as skin irritant (Schreiber, Bayer AG, 1980).
The eye irritation potential of 1-chloro-4 -nitrobenzene was investigated in 6 Himalayan rabbits according to the FDA guideline (federal register, Vol 38, No. 187, 1973). 100 mg undissolved test substance was applied into the conjunctival sac of one eye of each animal. The other untreated eye served as control. The eyes were rinsed 24 hours after application of the test substance.
The eye irritation reactions were examined and scored using the Draize method 1, 7 and 24, 48 and 72 hours after application.
After 1 hour the test substance induced the highest irritation index of 6. Therefore no classification according to FDA guideline is required (Hoechst AG, 1977). Although the study does not meet all requirement of the currently applicable guidelines, the non-irritating results from the supporting studies confirm the report.
Justification for classification or non-classification
No classification required.
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