Estrone

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

other: clinical data

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: endogenous human steroidal estrogen and approved drug with widespread therapeutic use for many years

Materials and methods

Study type:

human medical data

Endpoint addressed:

basic toxicokinetics

dermal absorption

acute toxicity: oral

acute toxicity: dermal

skin irritation / corrosion

eye irritation

skin sensitisation

repeated dose toxicity: oral

repeated dose toxicity: dermal

genetic toxicity

carcinogenicity

toxicity to reproduction / fertility

developmental toxicity / teratogenicity

Test material

Test material information

Constituent 1

Reference substance name:

Estrone

EC Number:

200-164-5

EC Name:

Estrone

Cas Number:

53-16-7

Molecular formula:

C18H22O2

IUPAC Name:

estrone

Test material form:

other: not applicable for read-across

Results and discussion

Results:

Estrone is an endogenous sex hormone and an approved drug since several decades. The active ingredient, synthetic estrone, is similar both chemically and biologically to endogenously produced human estrone. Estrone belongs to the category “steroidal estrogens” and is one of the pharmacologically less-active metabolites of 17β-estradiol which is the most potent of the naturally occurring estrogens (17ß-estradiol, estrone, estriol).The toxic effects of steroidal estrogens like estradiol <-> estrone are an exaggeration of the normal pharmacological effects and result in an increase of female characteristics. Estradiol and estrone are widely used for oral contraception and in post-menopausal hormonal therapy for many years. Therefore a wide base of clinical experience is available pointing out various types of adverse effects.