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Diss Factsheets
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EC number: 813-782-0 | CAS number: 5912-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 January - 22 April, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with isomer purity. Therefore full validation applies.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EUR 20268 EN: Guidance Document on the Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of chemical substances (European Commission, 2002)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- UK GLP compliance programme (inspected on 05 February 2014 / signed on 07 October 2015)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Percentile:
- D10
- Mean:
- 84.5 µm
- St. dev.:
- 0.7
- Percentile:
- D50
- Mean:
- 330 µm
- St. dev.:
- 3
- Percentile:
- D90
- Mean:
- 783 µm
- St. dev.:
- 3
- No.:
- #1
- Size:
- < 500 µm
- Distribution:
- 70 %
- No.:
- #2
- Size:
- < 100 µm
- Distribution:
- 13 %
- No.:
- #3
- Size:
- < 10 µm
- Distribution:
- 0 %
- No.:
- #4
- Size:
- < 4 µm
- Distribution:
- 0 %
- Conclusions:
- The test substance contains a limited fraction of particles fine enough to be inhaled, but they are not anticipated to reach the thoracic fraction.
Dust explosion potential should be considered. - Executive summary:
The size distribution of particles present in the test substance was assessed using particle size apparatus based on laser diffraction (cited in EUR 20268 EN Guidance Document).
Measurement was performed in duplicate.
The mean median diameter is 330 µm.
With regard to inhalation potential, about 13% of total particles are smaller than 100 µm, and 0% could reach the thoracic fraction (<10 µm).
Fine particles relevant to dust explosion hazard (<500 µm) account for 70%.
Reference
The overall mean values for the 10%, 50% and 90% quantile results are presented in the following table:
Parameter |
Size (μm) |
d(0.1) |
84 (mean of 85 and 84) |
d(0.5) |
330 (mean of 332 and 328) |
d(0.9) |
783 (mean of 781 and 785) |
The cumulative percentages of fractions below specific sizes were also determined to be as follows:
Fraction |
Cumulative volume % |
< 500 μm |
70 (mean of 70 and 70) |
< 100 μm |
13 (mean of 13 and 13) |
< 10 μm |
0 |
< 4 μm |
0 |
The curves show a Gaussian-type distribution, non-symetric (wider on the low-size edge).
Description of key information
Median diameter = 330 µm
Inhalable fraction (<100µm) = 13%, Thoracic fraction (<10µm) = 0%.
Dust particles (<500µm) = 70% (dust explosion potential)
Additional information
A fully reliable experimental study, conducted according to a method cited in EU guidance, and under GLP, is available. It is considered as a key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.