Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-661-1 | CAS number: 682-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent study following OECD guidelines under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Claimed but the GLP statement mentioned in the index is not attached to the report.
Test material
- Reference substance name:
- 2,2-bis(allyloxymethyl)butan-1-ol
- EC Number:
- 211-661-1
- EC Name:
- 2,2-bis(allyloxymethyl)butan-1-ol
- Cas Number:
- 682-09-7
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 2,2-bis[(prop-2-en-1-yloxy)methyl]butan-1-ol
- Details on test material:
- Trimethylolpropane diallyl ether 80 (P950128)
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not relevant
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Test solutions were 250 mL glass E-bottles with 100 mL solution that were incubated on a shaking table with approximately 100 µEm-2s-1 continuous illumination at a temperature of 24 ±1⁰C.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- The inoculum was taken from Toxicon's culture which originates from Swedish Environmental Protection Agency, Stockholm, Sweden.
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Post exposure observation period:
- No post observation period.
Test conditions
- Hardness:
- Not stated
- Test temperature:
- 24.5 - 25.0⁰C
- pH:
- 8.3 - 8.7 at the start and end of the exposure period for the control, 8.3 - 8.5 for the 100 mg/L treatment.
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- A single concentration of 100 mg/L
- Details on test conditions:
- The test solutions were incubated on a shaking table with approximately 100 µEm-2s-1 continuous illumination at a temperature of 24 ±1 ⁰C. The media and the nutrient concentration was the same in all test solutions and the control. The incubation period was 72 hours with sampling at 0, 24, 48 and 72 hours.
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- After 72 hours the mean control fluorescense was 46.3 (5 replicates, range 38.3 - 51.0). The mean value in the 100 mg/L treatment was 36.9 (2 replicates, range 34.8 - 39.0, one replicate was deemed to be an outlier and not used 2.7) The mean growth rate in the control was 1.53 and in the 100 mg/L treatment was 1.40.
The % inhibition in the 100 mg/L treatment was 8.1%, therefore the 72 h EC50 (based on nominal exposure concentrations) was >100 mg/L. - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- The result was based on observation of the data.
Any other information on results incl. tables
The concentration tested (100 mg/L) gave only a slight inhibition of the growth rate ie. the compound is not considered as acute toxic to the green algae, Selenastrum capricornutum. The results table is shown below;
Conc mg/L |
pH |
Fluorescence (chlorophyll a) |
Growth Rate, µ |
% inhibition |
|||||
0 h |
72 h |
0 h |
24 h |
48 h |
72 h (dil 3 times) |
72 h x 3 |
|||
Control 1 |
8.3 |
8.7 |
2.3 |
2.7 |
15.1 |
17.0 |
51.0 |
|
|
Control 2 |
|
|
2.0 |
3.0 |
14.2 |
16.6 |
49.8 |
||
Control 3 |
|
|
2.0 |
3.8 |
13.0 |
16.0 |
48.0 |
||
Control 4 |
|
|
2.1 |
3.6 |
11.7 |
14.8 |
44.4 |
||
Control 5 |
|
|
1.3 |
2.8 |
10.8 |
12.8 |
38.4 |
||
mean |
|
|
1.9 |
3.2 |
13.0 |
|
46.3 |
1.53 |
|
100 |
8.3 |
8.5 |
2.1 |
2.5 |
3.3 |
- |
2.7* |
|
|
100 |
|
|
2.0 |
3.3 |
11.4 |
13.0 |
39.0 |
||
100 |
|
|
1.9 |
3.3 |
10.3 |
11.6 |
34.8 |
||
mean |
|
|
2.0 |
3.0 |
8.3 |
|
36.9 |
1.40 |
8.1 |
* - valued determined to be an outlier and not used in the calculation of the results
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The concentration tested (100 mg/L) gave only a slight inhibition of the growth rate ie. the compound is not considered as acute toxic to the green algae, Selenastrum capricornutum.
- Executive summary:
The toxicity of TMPDE 80 to the green algae,Selenastrum capricornutum, was determined in the 72 hour test conducted according to OECD 201. The algae were exposed to a single concentration of TMPDE 80 of 100 mg/L. The 72hour EC50(based on growth rate) was observed to be >100 mg/L (based on nominal exposure concentrations). The corresponding NOEC was 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.