Registration Dossier
Registration Dossier
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EC number: 247-979-2 | CAS number: 26761-45-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient study detail to assign a reliable Klimisch rating.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
- Principles of method if other than guideline:
- Insufficient study detail.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-epoxypropyl neodecanoate
- EC Number:
- 247-979-2
- EC Name:
- 2,3-epoxypropyl neodecanoate
- Cas Number:
- 26761-45-5
- Molecular formula:
- C13H24O3
- IUPAC Name:
- (oxiran-2-yl)methyl 2,2-dimethyloctanoate
- Test material form:
- other: Liquid at room temperature.
- Details on test material:
- As per IUCLID5 Sections 1.1, 1.2. and 1.4.
Constituent 1
- Specific details on test material used for the study:
- See IUCLID Section 1.2 and 1.4.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Exposure was for 4 hours.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 240 mg/m3 (saturated vapor concentration) or approximately 26 ppm.
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 240 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- No data, assume none.
- Clinical signs:
- other: "No signs of intoxication were observed after exposure."
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Inhalation exposure of rats to a saturated vapour concentration of 2,3-epoxypropyl neodecanoate of approximately 240 mg/m3 (26 ppm) resulted in no mortalities. Therefore, the acute 4 hr LC50 value for 2,3-epoxypropyl neodecanoate is > 240 mg/m3 (26 ppm).
- Executive summary:
The acute 4 hr inhalation LC50 value of 2,3 -epoxypropyl neodecanoate to rats was > 240 mg/m3 (26 ppm).
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