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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Menthone Racemic
Author:
D. L. J. OPDYKE
Year:
1976
Bibliographic source:
Food and Cosm. Toxicology Vol 14, 1976, Pp 475-476,1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
A Closed-patch test was performed on human volunteers to assess the irritation potential of 2-isopropyl-5-methylcyclohexanone
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(±)-menthone
EC Number:
214-049-2
EC Name:
(±)-menthone
Cas Number:
1074-95-9
Molecular formula:
C10H18O
IUPAC Name:
2-isopropyl-5-methylcyclohexanone
Test material form:
liquid
Details on test material:
- Name of test material: 2-isopropyl-5-methylcyclohexanone
- Molecular formula: C10H18O
- Molecular weight: 154.2512g/mol
- Smiles notation: C1([C@@H](CC[C@@H](C1)C)C(C)C)=O
- InChl: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material: 2-isopropyl-5-methylcyclohexanone [(±)-menthone]
- Molecular formula: C10H18O
- Molecular weight: 154.2512g/mol
- Smiles notation: C1([C@@H](CC[C@@H](C1)C)C(C)C)=O
- InChl: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid

Test animals

Species:
other: humans
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: closed patch
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
8% in petrolatum
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
2-isopropyl-5-methylcyclohexanone was considered to be not irritating to human skin.
Executive summary:

A Closed-patch test was performed on human volunteers to assess the irritation potential of 2-isopropyl-5-methylcyclohexanone. 2-isopropyl-5-methylcyclohexanone was applied at 8% in petrolatum for 48 hrs. After 48 hrs 2-isopropyl-5-methylcyclohexanone was observed to cause no irritation in humans.

 

Therefore, 2-isopropyl-5-methylcyclohexanone was considered to be not irritating to human skin.