4-chlorotoluene

Endpoint summary

Description of key information

In 2 valid studies an oral LD50 ca. 2273 mg/kg bw (rat, male) and LD50 = 2389 mg/kg bw  (rat, female) were found. 
For acute dermal toxicity a LD50 > 5000 mg/kg bw was determined in 2 valid dermal toxicity test.
An inhalation-hazard test is available for acute inhalation toxicity. Rats exposed for 4182.6ppm (ca. 22000 mg/m³) for 4 hours 0/6 animals died. Rats exposed to 3950.9 ppm (ca. 21578 mg/m³) for 5 hours 3/6 animals died. Rats exposed to 3950.9 ppm (ca.  20781 mg/m³) or 4304.2 ppm (ca. or 4304.2 ppm (ca.22640 mg/m³) for 6 or 8 hours 6/6 animals died.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 273 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Additional information

The LD50 for acute oral toxicity is > 2000 mg/kg bw and the LD50 for acute dermal toxicity is > 5000 mg/kg bw.

For acute inhalation toxicity an inhalation-hazarzd test was conducted. The time- response curve seems to be very steep.

0/6 animals died after an exposure for 4 hours to ca. 22 mg/L, 3/6 rats died after an exposure for 5 hours to 21.5 mg/L.

All rats died after an exposure of 6 or 8 hours to ca. 20.7 or 22.6 mg/L, respectively.

Justification for classification or non-classification

Due to the results of the acute oral and dermal toxicity studies a classification is not justified.

According to Annex I to Directive 67/548/EEC p-chlorotoluene is classified as Xn, R 20; GHS: Acute Tox 4, H332

This classification will be adopted