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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

According to several QSAR estimations the compound is considered as acutely toxic to fish. The LC50 is estimated to be between 1 and 10 mg/L. 

Key value for chemical safety assessment

Additional information

The fish toxicity was calculated with three Toxicity classification models implemented in the Vega v1.1.0 platform and with EPI Suite ECOSAR program v.1.11. Based on the results of the EPI Suite calculation the LC50 of the test substance is between 10.037 mg/L (ECOSAR class calculation for Esters) and 34.913 mg/L(Neutral Organic SAR "Baseline Toxicity"). With the short-term toxicity-calculation using the Fish Acute (LC50) Toxicity model (KNN/Read-Across) v1.0.0 implemented in the VEGA platform v1.1.0 an LC50 of 8.28 mg/L was observed. The fathead minnow LC50 96h (EPA) model v1.0.7 resulted in an LC50 of 7.5 mg/L. The short-term toxicity-calculation using the Fish Acute (LC50) Toxicity classification (SarPy) v1.0.2 showed a LC50 in the range of 1 -1 0 mg/L for the test item. In summary, the LC50 for fish is estimated to be between 1 and 10 mg/L.

In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of diethyl butylmalonate (Q)SAR results were used for short-term toxicity to fish. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on diethyl butylmalonate are not provided.