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EC number: -
CAS number: -
In both an acute oral and an acute dermal toxicity study the LD50 was established to exceed 2000 mg/kg bw. The studies were performed according to OECD/EC guidelines and GLP principles.
Acute oral toxicity
FAT 41043/A TE was administered by oral
gavage to two subsequent groups of three female Wistar rats at 2000
mg/kg body weight according to OECD 423.
No mortality occurred. Hunched posture
and/or uncoordinated movements were noted among all animals on Day 1.
Red faeces and/or red staining of the back was shown by all animals
between Days 1 and 8. The mean body weight gain shown by the animals
over the study period was considered to be normal. No abnormalities were
found at macroscopic post mortem examination of the animals.
The oral LD50 value of FAT 41043/A TE in
Wistar rats was established to exceed 2000 mg/kg body weight. According
to the OECD 423 test guideline, the LD50 cut-off value was considered to
exceed 5000 mg/kg body weight.
Acute dermal toxicity
FAT 41043/A TE was administered to five
Wistar rats of each sex by a single dermal application at 2000 mg/kg
body weight for 24 hours according to OECD 402.
Lethargy, piloerection, hunched posture,
chromodacryorrhoea and/or ptosis were shown by all animals on Days 1
and/or 2. Red staining was noted on the treated skin-area of all animals
between Days 2 and 15. The changes noted in body weight gain in males
and females were within the normal range. Dark red discoloration of the
liver was noted in the female that was found dead. No further
abnormalities were found at macroscopic post mortem examination of the
The dermal LD50 value of FAT 41043/A TE in
Wistar rats was established to exceed 2000 mg/kg body weight.
Based on these results, FAT 41043/A TE does
not have to be classified and has no obligatory labelling requirement
for acute oral and dermal toxicity according to the:
- Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) of the United Nations
- Regulation (EC) No 1272/2008 on
classification, labelling and packaging of substances and mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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