Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 October 2011- 31 January 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (2008)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 92.4 other: ng/l
- Temp.:
- 20 °C
- pH:
- 5.7
- Remarks on result:
- other: Flowrate 24 ml/h
- Water solubility:
- 40.4 other: ng/l
- Temp.:
- 20 °C
- pH:
- 5.6
- Remarks on result:
- other: Flowrate 12 ml/h
- Water solubility:
- 24.5 other: ng/l
- Temp.:
- 20 °C
- pH:
- 5.9
- Remarks on result:
- other: Flowrate: 6 ml/h
- Details on results:
- With the flow rates of 6, 12 and 24 ml/h a tendency to decreased values with decreasing the flow rate was observed. As a result of it the maximum difference (MD) on the mean values of the samples at the different flow rates was >30 %. The flow rate of 6 ml/h was considered to be the minimum flow rate experimentally applicable. According to this the water solubility of the test substance is given as ≤24.5 ng/l.
- Conclusions:
- Interpretation of results: insoluble (<0.1 mg/L)
The water solubility of the test substance at 20 °C and pH 5.6-5.9 was ≤24.5 ng/l.
Reference
The turbidity of the eluates was <0.1 NTU. According to this, no undissolved particles were detected in the eluates. A small response of the test substance was detected in the samples from the blank column. The reason for detection was mostly likely due to carry over from the analytical system since a similar response was observed in the analytical blanks. The responses of the blank columns were significantly below the responses of the test samples. According to this it was concluded that the responses had no effect on the results of the water solubility test for the test substance.
Description of key information
≤24.5 ng/l at 20 °C (OECD 105, EC A.6: column elution method)
Key value for chemical safety assessment
- Water solubility:
- 0.025 µg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
