Registration Dossier
Registration Dossier
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EC number: 213-448-9 | CAS number: 950-33-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25-Mar-2015 to 29-Sep-2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- other: Slow-Stirring
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.65
- Temp.:
- 25 °C
- pH:
- 5.9
- Conclusions:
- A log Pow of 4.65 (at 25 °C, pH 5.9) was determined for the test substance according to OECD Guideline 123.
Reference
Results
Table of results
Replicate number |
Test duration (h) |
Measured concentration |
Pow |
Log Pow |
||||
in n-octanol (mg/L) |
in Aq. phase (mg/L) |
Single |
Mean |
SD +/- |
CV |
|||
1 |
90.08 |
18442 |
0.419 |
43993 |
4.64 |
4.65 |
0.02 |
0.40 |
95.08 |
17416 |
0.404 |
43088 |
4.63 |
||||
114.08 |
19546 |
0.411 |
47509 |
4.68 |
||||
119.08 |
18926 |
0.416 |
45473 |
4.66 |
||||
2 |
90.08 |
17700 |
0.421 |
42043 |
4.62 |
4.65 |
0.02 |
0.39 |
95.08 |
18152 |
0.402 |
45109 |
4.65 |
||||
114.08 |
19544 |
0.421 |
46423 |
4.67 |
||||
119.08 |
18394 |
0.409 |
44973 |
4.65 |
||||
3 |
90.08 |
17232 |
0.427 |
40337 |
4.61 |
4.64 |
0.03 |
0.54 |
|
95.08 |
18498 |
0.414 |
44724 |
4.65 |
|||
|
114.08 |
18896 |
0.411 |
45931 |
4.66 |
|||
|
119.08 |
18782 |
0.418 |
44976 |
4.65 |
|||
Log Pow, Av = 4.649
σ Log Pow, Av = 0.001
aq. phase = Aqueous phase
Pow = Partition coefficient (n-octanol / water)
Log Pow = Decadic logarithm of the partition coefficient (n-octanol / water)
SD = Standard Deviation
CV = Coefficient of variation (%)
Log Pow, Av = Weighted average value of log Pow
σLog Pow, Av = Weighted standard deviation
Conclusions
The partition coefficient (n-octanol/water) (log POW) of the test substance was determined at a test temperature of 25 ±1 °C and at a pH value of 5.9 from three independent replicates (test vessels) with four sub-replicates (samples) to be 4.649 ±0.001.
Description of key information
Log Pow: 4.65 at 25 °C, pH 5.9 (OECD Guideline 123, slow stirring)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.65
- at the temperature of:
- 25 °C
Additional information
A log Pow value of 4.65 (at 25 °C, pH 5.9) was determined for the tet substance according to OECD Guideline 123.
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