Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Transformation products:
no
Total recovery of test substance (in %)
% Recovery:
82 - 108
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
20 °C
Hydrolysis rate constant:
2.118 h-1
DT50:
0.3 h
Key result
pH:
7
Temp.:
20 °C
Hydrolysis rate constant:
0.018 h-1
DT50:
38.7 h
Key result
pH:
9
Temp.:
20 °C
Hydrolysis rate constant:
0.005 h-1
DT50:
138.6 h

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The test item is hydrolytically unstable at pH4, pH7 and pH9
Executive summary:

The test item is hydrolytically unstable at pH4, pH7 and pH9