Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 249 mg/L
- Temp.:
- 20 °C
- pH:
- 8.6 - 8.7
- Details on results:
- The saturation equilibrium set in after 24 hours. The 48 h and 72 h results were used for the calculation (see Table 1).
Appearance of the sample preparations:
After equilibration, the preparations were opalescent emulsions. Centrifugation and filtration resulted in macroscopically clear solutions. - Conclusions:
- The environmentally relevant solubility might be lower than the determined solubility since, although macroscopically clear solutions have been reported, the existence of microemulsions cannot be excluded.
Reference
Table 1:
Measured concentration after 24 hours (mg/L) |
pH |
Measured concentration after 48 hours (mg/L) |
pH |
Measured concentration after 72 hours (mg/L) |
pH |
Solubility of the test item (mg/L) |
195 |
8.60 |
269 |
8.61 |
214 |
8.65 |
|
197 |
8.52 |
235 |
8.56 |
249 |
8.60 |
249 ± 27.3 |
182 |
8.50 |
287 |
8.59 |
238 |
8.61 |
|
Mean: 191 |
- |
Mean: 264 |
- |
Mean: 234 |
- |
RSD%=10 |
Description of key information
249 mg/L at 20 °C, pH 8.6-8.7 (OECD 105 and EU A.6)
Key value for chemical safety assessment
- Water solubility:
- 249 mg/L
- at the temperature of:
- 20 °C
Additional information
The environmentally relevant solubility might be lower than the determined solubility since, although macroscopically clear solutions have been reported, the existence of microemulsions cannot be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
