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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Description of key information

QSAR model, iSafeRat holistic approach v1.4, key study, validity 2:
48h-EC50 = 13 mg/L (95% CL: 9.2 - 18 mg/L).

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
13 mg/L

Additional information

To assess the toxicity of the registered substance to aquatic algae, one data point is available.

The value (KREATiS, 2015), assessed as a key datapoint, is a QSAR. This QSAR prediction (iSafeRat holistic approach v1.4) was performed on the registered substance, to assess the acute toxicity of the substance to daphnids. This QSAR has been validated to be compliant with the OECD recommendations for QSAR modelling (OECD, 2004) and predicts the endpoint value which would be expected when testing the substance under experimental conditions in a laboratory following OECD Guideline 202. The immobility of the daphnids was determined using a validated QSAR for the Mode of Action in question, (ester). The QSAR is based on validated data for a training set of 12 chemicals derived from 48-hour tests on daphnids, for which the concentrations of the test substance had been determined by chemical analyses over the test period. The substance falls within the applicability domain of the model. The 48h-EC50 based on mobility was determined to be 13 mg/L (95% CL: 9.2 - 18 mg/L).