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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
Reason / purpose:
assessment report

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Molecular structure-dependent cytotoxic effect of ascorbate derivates
Author:
Tsao CS, Young M
Year:
1995
Bibliographic source:
In Vitro Cell.Dev.Biol. 31:87-90, February 1995
Reference Type:
secondary source
Title:
No information
Author:
Zasshi
Year:
1963
Bibliographic source:
Journal of Medical Society of Toho University. Vol 10, Pag. 1 1963 (CHemIDplus)
Reference Type:
secondary source
Title:
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program
Author:
NCI
Year:
1986
Bibliographic source:
Vol. JAN1986 (ChemIDplus)
Reference Type:
secondary source
Title:
No information
Author:
Yakuri
Year:
1976
Bibliographic source:
Pharmacometrics. Vol 12, p.131 (ChemIDplus)
Reference Type:
publication
Title:
SIDS Data Set on L-Ascorbic Acid (Vitamin C)
Author:
UNEP publications
Year:
1990
Bibliographic source:
www.inchem.org/documents/sids/sids/50817.htmlb
Reference Type:
publication
Title:
SIDS Data Set on Ethanol
Author:
UNEP Publications
Year:
2004
Bibliographic source:
www.inchem.org/documents/sids/sids/64175.pdf
Reference Type:
secondary source
Title:
No information
Author:
FAO
Year:
1974
Bibliographic source:
FAO Nutrition Meetings Report Series. Vol 53A, p. 146, 1974 (ChemIDplus)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: different guidelines followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
different test materials tested

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 13 - <= 10 000 other: microG
Based on:
not specified
Remarks on result:
other: results based on many compounds
Sex:
not specified
Dose descriptor:
LD50
Effect level:
25 070 mg/kg bw
Based on:
not specified
Remarks on result:
other: mouse, Zasshi (1963)
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 367 mL/kg bw
Based on:
not specified
Remarks on result:
other: mouse, NCI (1986)
Sex:
not specified
Dose descriptor:
LD50
Effect level:
11 900 mg/kg bw
Based on:
not specified
Remarks on result:
other: rat, Yakuri (1976)
Sex:
not specified
Dose descriptor:
LD50
Effect level:
25 000 mg/kg bw
Based on:
not specified
Remarks on result:
other: mouse, FAO (1974)

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met