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EC number: 219-969-8 | CAS number: 2587-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study does not specify any particular guidelines but was conducted to sound scientific principles; possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results. The study report is in German.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The methodology used was similar to that outlined in OECD Guideline 401 (Acute Oral Toxicity). A limit dose of the test material was administered to male and female rats.
- GLP compliance:
- no
- Remarks:
- Study conducted in 1968, prior to introduction of GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Chlorotrioctylstannane
- EC Number:
- 219-969-8
- EC Name:
- Chlorotrioctylstannane
- Cas Number:
- 2587-76-0
- Molecular formula:
- C24H51ClSn
- IUPAC Name:
- chlorotrioctylstannane
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 90 to 120 g
- Acclimation period: 6 days
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 g CMC in 100 mL distilled water
- Details on oral exposure:
- - Formualtion: Emulsion
- Substance concentration: 40 g in 100 mL - Doses:
- 1 dose at 4.0 g/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 12 days
- Necropsy of survivors performed: Yes. The following regions of the body were examined using the appropriate aids (e.g. magnifying glass, stereomicroscope, instruments): coat and skin, eyes, nose, mouth, ear, anus, preputial, vulva, subcutaneous tissue, stomach, pelvic cavity and peritoneum, oesophagus, small intestine, colon, mesenteric lymph nodes, liver, pancreas, spleen, kidneys, bladder, seminal vesicle, prostrate, testicle, epididymis, ovary, uterus, vagina*, chest cavity and pleura, heart, lung, trachea, thymus, cerebrum*, middle ear and application site.
Parameters marked with * only examined in cases of suspected pathology due to the intoxication or other special pathological-anatomical findings.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 other: g/kg
- Based on:
- test mat.
- Mortality:
- All ten animals survived the testing period.
- Clinical signs:
- other: In five animals (4 males/1 female) slight swelling of the spleen was observed. Five animals (1 male/4 females) appeared to be unaffected.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria
- Conclusions:
- Under the conditions of the study, the LD50 was determined to be > 4.0 g/kg in male and female rats.
- Executive summary:
The potential of the test material to cause acute oral toxicity in the rat was investigated in accordance with sound scientific principles. The test material was administered to 5 male and 5 female rats as a limit dose in an emulsion, using a vehicle of carboxymethylcellulose (0.5 g CMC in 100 mL distilled water). The rats were treated with 4 g/kg of the test material.
Animals were observed for mortality and abnormal clinical signs for a period of 12 days after administration. All animals were weighed prior to treatment. All ten animals survived the test and were sacrificed at the end of the 12 day observation period.
In five animals (4 males/1 female), slight swelling of the spleen was observed whilst five animals (1 male/4 females) appeared to be unaffected.
Under the conditions of the study, the LD50 was determined to be > 4.0 g/kg in male and female rats.
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