Ethanone, 1-[4-(acetyloxy)-3-[(acetyloxy)methyl]phenyl]-

Guidance on Safe Use

First-aid measures

INGESTION

Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

INHALATION

Using appropriate personal protective equipment, move exposed subject to fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen as appropriate. The exposed subject should be kept warm and at rest. Obtain medical attention in cases of known or possible over exposure, or with symptoms including chest pain, difficulty breathing, loss of consciousness or other adverse effects, which may be delayed.

SKIN CONTACT

Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

EYE CONTACT

Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

NOTES TO HEALTH PROFESSIONALS

MEDICAL TREATMENT

In allergic individuals, exposure to this material may require treatment for initial or delayed allergic symptoms and signs. This may include immediate and/or delayed treatment of anaphylactic reactions. Treat according to locally accepted protocols. For additional guidance, refer to the local poison control information centre.

Medical Conditions Caused or Aggravated by Exposure

Ocular symptoms may be indicative of allergic reaction.

Health Surveillance Procedures

The need for pre-placement and periodic health surveillance must be determined by risk  assessment. Following assessment, if the risk of exposure is considered significant then exposed individuals should receive health surveillance focused on detecting skin conditions. In the event of overexposure, individuals should receive post exposure health surveillance focused on detecting skin conditions and other allergy symptoms.

ANTIDOTES

No specific antidotes are recommended.

Fire-fighting measures

FIRE AND EXPLOSION HAZARDS

This material is non-combustible.

Dust clouds are potentially sensitive to ignition from incendive electrostatic discharges.

Dust clouds are of very low sensitivity to ignition from hot surfaces.

No ignition or exotherm of a powder layer observed up to 400 °C.

Ignition of a dust cloud produces a weak dust explosion.

Low pressure between 4 and 6 bar is produced during a dust explosion.

SUITABLE EXTINGUISHING MEDIA

No special requirements needed. Water is recommended for fires involving packaging.

SPECIAL PROTECTIVE EQUIPMENT AND PRECAUTIONS FOR FIREFIGHTERS

Since toxic, corrosive or flammable vapours might be evolved from fires involving this material, self contained breathing apparatus and full protective equipment are recommended for firefighters. Move containers from the fire area if possible without increased personal risk. If possible, contain and collect firefighting water for later disposal.

SPECIFIC HAZARDS ARISING FROM THE MATERIAL

Toxic, corrosive or flammable thermal decomposition products are expected when the material is exposed to fire.

Accidental release measures

PERSONAL PRECAUTIONS

Fence or cordon the affected area and do not allow individuals to touch or walk through the spilled material unless wearing appropriate protective clothing. Avoid dust generation.

ENVIRONMENTAL PRECAUTIONS

If spill is outdoors, cover with plastic sheet to minimise spreading or contact with rain. For large spills, take precautions to prevent entry into waterways, sewers, or surface drainage systems.

CLEAN-UP METHODS

Collect and place it in a suitable, properly labelled container for recovery or disposal.

DECONTAMINATION PROCEDURES

No specific decontamination or detoxification procedures have been identified for this material. Consider use of water, detergent solutions, or other soluble solvents, for clean-up and decontamination operations. Surfaces should be decontaminated.

Handling and storage

PRECAUTIONS FOR SAFE HANDLING

GENERAL REQUIREMENTS

Avoid dispersion as a dust cloud.

Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to provide routine control of fire and explosion hazards during handling of this material.

IGNITION CONTROLS

Bond and earth (ground) all plant and equipment to ensure that no isolated conductors are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges of many hundreds of milli-Joules.

Consider earthing (grounding) personnel dealing with dusty operations. An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but have been recorded up to 100 mJ.

The maximum surface temperature of enclosures potentially exposed to this material should be the lower of the values obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less than the minimum ignition temperature of the dust layer, with a maximum temperature of 325 °C.

PROTECTIVE SYSTEMS

Assess operations based upon available dust explosion information to determine the suitability of preventive or protective systems as precautionary measures against possible dust explosions. If prevention is not possible, consider protection by use of containment, venting or suppression of dust handling equipment. Where explosion venting is considered the most appropriate method of protection, vent areas should preferably be calculated based on the Kst rather than the St value.

If nitrogen purging is considered as the protective system, it must operate with an oxygen level below the limiting oxygen concentration. The system should include an oxygen monitoring and shut-down facility in the event of excessive oxygen being detected.

At both ambient and low humidity, this material is of appreciable conductivity. Generation and accumulation of electrostatic charge is considered unlikely to occur when handled in an earthed (grounded) environment.

At ambient humidity, this material has an extremely fast charge relaxation time. Accumulation of electrostatic charge is considered unlikely to occur when handled in an earthed (grounded) environment.

At low humidity, this material has a fast charge relaxation time. Accumulation of electrostatic charge is considered unlikely to occur when handled in an earthed (grounded) environment. At the end of the charge accumulation process charge is expected to be readily lost to earth (ground).

CONDITIONS FOR SAFE STORAGE

Keep in tightly closed containers or packages away from moisture and away from sources of ignition.

Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately 20 degrees C).

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, nos

Chemical name:

Diacetate

Language:

English

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, nos

Chemical name:

Diacetate

Language:

English

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, nos

Chemical name:

Diacetate

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 3077

Shipping information

Proper shipping name and description:

Environmentally hazardous substance, solid, nos

Chemical name:

Diacetate

Remarks

SpecialProvisions

Exposure controls / personal protection

ENGINEERING CONTROLS:

EXPOSURE CONTROLS

This material has been assigned to GlaxoSmithKline Occupational Hazard Category 4 with a

hygiene guide of <10 mcg/m3. An Exposure Control Approach (ECA) is established for operations

involving this material based upon the OEL/Occupational Hazard Category and the outcome of a

site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more

information about how ECA's are assigned and how to interpret them.

CONTAINMENT

Open handling may result in overexposure. It is strongly advised that dedicated areas and

containment, such as glove boxes, isolators, and enclosed material transfer systems be used to

prevent personnel exposure and spread of contamination.

VENTILATION

Local Exhaust Ventilation (LEV) is not appropriate at this level, since total containment should

usually be used.

ADMINISTRATIVE

Strict control of access to the working area is essential. Only trained personnel should enter the

area during operations. Adopt procedures to prevent contamination of working materials and

adjacent areas.

PERSONAL PROTECTIVE EQUIPMENT:

EYE PROTECTION

Wear approved safety glasses with side shields or cover goggles if eye contact is possible.

GLOVES

The selection of gloves for a specific activity must be based on the material's properties and on possible permeation and degradation that may occur under the circumstances of use. Glove selection must take into account any solvents and other hazards present. Potential allergic reactions can occur with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised if insufficient data are available and further guidance should be sought from your local EHS department.

RESPIRATORS

When isolation is not possible, respiratory protective equipment (RPE) should be combined with applicable protective equipment. Follow local regulations for respirator use in the workplace.

OTHER EQUIPMENT OR PROCEDURES

An eye wash station should be available. When isolation is not possible in production areas, appropriate personal protective equipment must be used. Consider additional control procedures for maintenance, cleaning and emergencies.

Stability and reactivity

CONDITIONS TO AVOID:

Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.

Disposal considerations

DISPOSAL RECOMMENDATIONS:

Collect for recycling or recovery if possible. Dispose of material on site via a licenced waste water treatment plant provided that it will achieve an effluent quality equivalent to at least secondary treatment.

REGULATORY REQUIREMENTS:

Observe all local and national regulations when disposing of this material.