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Environmental fate & pathways

Hydrolysis

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Description of key information

Diethanolamine and Bisphenol A are stable at pH 4, 7, 9. At 25 °C the following DT50 values resulted:
pH 7: 1935 h (Mannich Base 1) and 976 h (Mannich Base 2)
pH 9: 238.1 h (Mannich Base 1) and 117.9 h (Mannich Base 2)

Key value for chemical safety assessment

Half-life for hydrolysis:
117.9 h
at the temperature of:
25 °C

Additional information

One experimental study according to OECD 111 is available investigating the abiotic hydrolysis of the test substance (GLP; Neuland, 2015). Diethanolamine is known to be stable in aqueous solutions. Thus, the study was focused on the hydrolysis of the remaining constituents Bisphenol A, Mannich Base 1 and Mannich Base 2.
A preliminary study was performed at pH 4, 7 and 9 at 50 °C for 5 d. As a result, the components Bisphenol A, Mannich Base 1 and Mannich Base 2 are considered to be stable at pH 4 at 50 °C. Thus, it can be assumed that the constituents are also stable at 25 °C.
The main test was performed at 25 °C with Mannich Base 1 and Mannich Base 2 at pH 7 and 9 for 32 d (hydrolysis was < 90 %). DT50 values of 1935 h (Mannich Base 1, pH 7), 238.1 h (Mannich Base 1, pH 9), 976 h (Mannich Base 2, pH 7) and 117.9 h (Mannich Base 2, pH 9) were calculated. The hydrolysis products of Mannich Base 1 and Mannich Base 2 were analysed by HPLC-UV/LC-MS. 2-(Hydroxymethyl)-4-[1-(p-hydroxyphenyl)-1-methylethyl]phenol is the transformation product of Mannich Base 1 at pH 7 and 9. 4-{1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-1-methylethyl}-2-(hydroxymethyl)phenol is the transformation product from Mannich Base 2 at pH 7 and 9. Diethanolamine is the third transformation product from hydrolysis.
In conclusion, hydrolysis is not a significant degradation process in the environment.