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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(4aR,4bS,6aS,9aS,9bR,11aR)-4a,6a-Dimethyltetradecahydro-1H-indeno[5,4-f]quinoline-2,7-dione
EC Number:
616-323-0
Cas Number:
76318-69-9
Molecular formula:
C18H27NO2
IUPAC Name:
(4aR,4bS,6aS,9aS,9bR,11aR)-4a,6a-Dimethyltetradecahydro-1H-indeno[5,4-f]quinoline-2,7-dione

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
12.8 mg/L
Nominal / measured:
estimated
Remarks on result:
other: Database: Aquatic Japan MoE

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that finasteride saturated lactam is hazardous to the aquatic invertebrates (Daphnia magna). The result meets the requirement of Aquatic Acute Category 3.