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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 1994 - February 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
gas saturation method
Key result
Test no.:
#1
Temp.:
30 °C
Vapour pressure:
< 0.003 Pa
Remarks on result:
other: < 0.000021 mmHg at 30 ºC
Key result
Test no.:
#5
Temp.:
40 °C
Vapour pressure:
< 0.003 Pa
Remarks on result:
other: < 0.000026 mmHg at 40 ºC

Validation percent recovery:

Percent recovery of TS (spiking 25 µg): > 99%

Table 1. Individual results.    

Test No.

Saturator

Temperature

(ºC ± 0.5)

N2 flow rate (mean value, L/h)

Total volume of N2 passed through the saturator (L)

Quantity of TS in the traps (μg)*

Vapour density of the TS (μg/L)

Vapour pressure (mm Hg)

Vapour pressure (Pa)

1

30

0.40

34.3

< 11

< 0.31

< 2.1E-6

< 2.8E-3

2

30

0.94

82.6

< 9

< 0.11

< 7.8E-6

< 1.0E-3

3

30

1.60

40.2

< 10

< 0.24

< 1.7E-6

< 2.2E-3

4

30

1.60

40.5

< 10

< 0.25

< 1.7E-6

< 2.2E-3

5

40

0.51

26.9

< 10

< 0.37

< 2.6E-6

< 3.4E-3

6

40

1.03

53.6

< 9

< 0.17

< 1.2E-6

< 1.6E-3

7

40

1.40

56.4

< 10

< 0.17

< 1.2E-6

< 1.6E-3

*The TS concentration was below the detection limit.

Conclusions:
The vapour pressure of the test substance was:
<2.8E-03 (2.1E-05 mmHg) at 30 ºC
<3.4E-03 Pa (2.6E-05 mmHg) at 40 ºC
Executive summary:

The vapour pressure of the test substance was determined by de gas saturation method (EU Method A.4).

The vapour pressure for Fosfomycin PEA salt was < 2.8E-03 (2.1E-05 mmHg) at 30 ºC and <3.4E-03 Pa (2.6E-05 mmHg) at 40 ºC.

Description of key information

Key study: Test method according to EU Method A.4. GLP study.

Key value for chemical safety assessment

Vapour pressure:
0.003 Pa
at the temperature of:
30 °C

Additional information

Key study: Test method according to EU Method A.4. GLP study. The vapour pressure for Fosfomycin PEA salt was < 2.8E-03 (2.1E-05 mmHg) at 30 ºC and <3.4E-03 Pa (2.6E-05 mmHg) at 40 ºC.