Registration Dossier

Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Effects of PCBs, DDT, and mercury compounds in chickens and Japanese quail
Author:
Scott ML
Year:
1977
Bibliographic source:
Fed Proc. 1977 May;36(6):1888-93.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
The reprotoxicity was performed on white leghorn chickens by mercury sulphate(7783-35-9)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Mercury sulphate
- Molecular formula: H2O4S.Hg
- Molecular weight : 298.67 g/mol
- Smiles notation: [O-]S(=O)(=O)[O-].[Hg+2]
- InChl : InChI=1S/Hg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
- Substance type: Solid
- Physical state: Inorganic
- Impurities (identity and concentrations): No data

Test animals

Species:
other: Chickens
Strain:
other: Breed: white leghorn
Sex:
female
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: feed
Type of inhalation exposure (if applicable):
not specified
Vehicle:
other: Diet
Details on exposure:
No data available
Details on mating procedure:
No data available
Analytical verification of doses or concentrations:
not specified
Details on analytical verification of doses or concentrations:
No data available
Duration of treatment / exposure:
No data available
Frequency of treatment:
Daily
Details on study schedule:
No data available
Doses / concentrations
Remarks:
Doses / Concentrations:
100 and 200 ppm (100 and 200 mg/kg)(Convert by general google converter)
Basis:
nominal in diet
No. of animals per sex per dose:
No data available
Details on study design:
No data available
Positive control:
No data available

Examinations

Parental animals: Observations and examinations:
No data available
Oestrous cyclicity (parental animals):
No data available
Sperm parameters (parental animals):
No data available
Litter observations:
No data available
Postmortem examinations (parental animals):
No data available
Postmortem examinations (offspring):
No data available
Statistics:
No data available
Reproductive indices:
No data available
Offspring viability indices:
No data available

Results and discussion

Results: P0 (first parental generation)

General toxicity (P0)

Clinical signs:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Organ weight findings including organ / body weight ratios:
not specified
Histopathological findings: non-neoplastic:
not specified
Other effects:
not specified

Reproductive function / performance (P0)

Reproductive function: oestrous cycle:
not specified
Reproductive function: sperm measures:
not specified
Reproductive performance:
not specified

Effect levels (P0)

Dose descriptor:
LOEL
Effect level:
200 mg/kg diet
Based on:
test mat.
Sex:
female
Basis for effect level:
other: egg production, hatchability, shell quality, morbidity and mortality

Results: F1 generation

General toxicity (F1)

Clinical signs:
not specified
Mortality / viability:
not specified
Body weight and weight changes:
not specified
Sexual maturation:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Histopathological findings:
not specified

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The endpoint for reprotoxicity to chicken by mercury sulphate(7783-35-9) was found to be LOEL at 200 mg/kg concentration.
Executive summary:

The reprotoxicity was performed on white leghorn chickens by mercury sulphate(7783-35-9) .Chickens are given chemical at dietary level as 100 and 200 mg/kg and after treatment little effect was observed on egg production, hatchability, shell quality, morbidity and mortality.

Therefore, the endpoint for reprotoxicity to chicken by mercury sulphate(7783-35-9) was found to be LOEL at 200 mg/kg concentration.