3'-aminoacetophenone

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Data source

Reference

Reference Type:

review article or handbook

Title:

Acute Toxicity

Author:

German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (Länder)

Year:

1996

Bibliographic source:

GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States; GSBL Datenlieferung Sommer 1996

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as per mentioned below

Principles of method if other than guideline:

Acute oral toxicity performed on rat by using test chemical 3'-aminoacetophenone

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3'-aminoacetophenone

EC Number:

202-722-3

EC Name:

3'-aminoacetophenone

Cas Number:

99-03-6

Molecular formula:

C8H9NO

IUPAC Name:

1-(3-aminophenyl)ethan-1-one

Details on test material:

- Name of test material: 3’-aminoacetophenone
- Molecular formula: C8H9NO
- Molecular weight: 135.16 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
Source: No data
Age at study initiation: No data
Weight at study initiation: 90 -120 g
Fasting period before study: Not fasted
Housing: No data
Diet (e.g. ad libitum): No data
Water (e.g. ad libitum): No data
Acclimation period: No data

ENVIRONMENTAL CONDITIONS
Temperature (°C): No data
Humidity (%):No data
Air changes (per hr): No data
Photoperiod (hrs dark / hrs light): No data

IN-LIFE DATES: From: No data To: No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: It was necessary to bring the volume administered per rat in 1ml to 10 ml, the substance was dissolved in water, corn oil or 1% Tergitol 7 Penetrant (an aqueous solution of 25% 3 Sodium,9diethyl6tridecanolsulfat)

Details on oral exposure:

VEHICLE
Concentration in vehicle: It was necessary to bring the volume administered per rat in 1ml to 10 ml
Amount of vehicle (if gavage): 1 -10 ml
Justification for choice of vehicle: No data
Lot/batch no. (if required): No data
Purity: No data

MAXIMUM DOSE VOLUME APPLIED:
No data

Doses:

Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage.

No. of animals per sex per dose:

5 males/ dose

Control animals:

not specified

Details on study design:

Duration of observation period following administration: 14 days (or other?) : 14 days

Statistics:

Based on the occurring during this time
Mortalities were statistically the most likely
LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.

Results and discussion

Preliminary study:

no data

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

1 870 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Mortality

Mortality:

no data

Clinical signs:

other: no data

Gross pathology:

no data

Other findings:

no data

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

For the study 90- 120g male Carworth Wistar rats, were used. Each dose group contained 5 rats. Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage. The animals had not previously fasted. A total of 157 substances were investigated. The work does not contain information about which substances and which were tested undiluted in dissolved or suspended form.
Based on the occurring during this time, Mortalities were statistically the most likely LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.
The acute oral LD50 value for 3’-aminoacetophenone in rats is 1870mg/kg

Executive summary:

For the study 90- 120g male Carworth Wistar rats, were used. Each dose group contained 5 rats. Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage. The animals had not previously fasted. A total of 157 substances were investigated. The work does not contain information about which substances and which were tested undiluted in dissolved or suspended form.

 It was necessary to bring the volume administered per rat in 1ml to 10 ml, the substance was dissolved in water, corn oil or 1% Tergitol 7 Penetrant (an aqueous solution of 25% 3 Sodium,9diethyl6tridecanolsulfat)

After administration of the test chemical the rats were observed for 14 days.

Based on the occurring during this time, Mortalities were statistically the most likely LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.

The acute oral LD50 value for 3’-aminoacetophenone in rats is 1870mg/kg