Registration Dossier
Registration Dossier
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EC number: 205-476-5 | CAS number: 141-27-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: literature, too little details on experimental design given
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Compound Geraniol Forms Contact Allergens on Air Exposure. Identification and Quantification of Oxidation Products and Effect on Skin Sensitization
- Author:
- L.Hagvall, C.Backtorp, S.Svensson, G.Nyman, A.Borje and A.-T.Karlberg
- Year:
- 2 007
- Bibliographic source:
- Chem. Res. Toxicol. 2007, 20, 807-814
Materials and methods
- Principles of method if other than guideline:
- acc. to Kimber et al, 1995
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- (E)-3,7-dimethylocta-2,6-dienal
- EC Number:
- 205-476-5
- EC Name:
- (E)-3,7-dimethylocta-2,6-dienal
- Cas Number:
- 141-27-5
- Molecular formula:
- C10H16O
- IUPAC Name:
- 3,7-dimethylocta-2,6-dienal
- Reference substance name:
- Geranial
- IUPAC Name:
- Geranial
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
Study design: in vivo (LLNA)
- Vehicle:
- not specified
- Concentration:
- 1%, 10%, and 30%
- No. of animals per dose:
- 4
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 1%: SI = 0.71 10%: SI = 4.3 30%: SI = 11.3 EC3 = 6.8%
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 1%: 426 dpm/node 10%: 2568 dpm/node 30%: 6831 dpm/node
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- According to the authors, Geranial is considered a moderate sensitizer.
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