Registration Dossier
Registration Dossier
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EC number: 200-625-0 | CAS number: 66-27-3
Endpoint summary
Administrative data
Description of key information
Hydrolysis
The half-life of Methyl methanesulfonate (CAS no. 66 -27 -3) was determined to be 4.56 h (at 20ᵒC), 9.66 hrs and 77 hrs (at 25ᵒC) respectively, indicates that the chemical Methyl methanesulfonate undergoes moderate to slow hydrolysis in water.
Additional information
Hydrolysis
Experimental key studyfor the target chemical Methyl methanesulfonate (CAS no. 66-27-3) and supporting study for its structurally similar read across substance were reviewed for hydrolysis end point which are summarized as below:
In an experimental key study from peer reviewed journal (Arthur R et. al; 1987) and authoritative database (HSDB and PubChem, 2017), the half-life of Methyl methanesulfonate (CAS no. 66 -27 -3) was determined to be 4.56 h (at 20ᵒC), 9.66 hrs and 77 hrs (at 25ᵒC) respectively.
For the read across chemical Isopropyl methanesulfonate (CAS no. 926-06-7), the half-lives of chemical Isopropyl methanesulfonate was determined to be 4.56 hrs at 25°C and 77 hrs at 20°C respectively (HSDB, 2017).
Thus, based on the overall reported results for target chemical Methyl methanesulfonate (from authoritative database HSDB and PubChem, 2017& from peer reviewed journal) and the study for the read across chemical (from authoritative database HSDB, 2017), it can be concluded that the test substance Methyl methanesulfonate can be considered to undergoes moderate to slow hydrolysis in water.
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