Triphenylphosphine oxide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; nominal atmosphere concentration); however, this test design is unsuitable for solids

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

nominal determination of the test atmosphere by rewighing

GLP compliance:

no

Test type:

other: Inhalation hazard test (IHT)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Triphenylphosphine oxide

EC Number:

212-338-8

EC Name:

Triphenylphosphine oxide

Cas Number:

791-28-6

Molecular formula:

C18H15OP

IUPAC Name:

triphenylphosphine oxide

Details on test material:

- Name of test material (as cited in study report): Triphenylphosphinoxid
- Physical state: crystalline powder
- Purity: pure p.a.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: males: 170 g, females 164.5 g

ENVIRONMENTAL CONDITIONS
not reported

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Rats exposed for 8 h to a dust atmosphere.
Dust was generated by pumping 200 l/h dry air (no CO2) through the powder column of about 5 cm above a fritted glass disc in a glass cylinder. The glass cylinder was heated in a water bath. Temperature in the exposure chamber was room temperature.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

not applicable

No. of animals per sex per dose:

12

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: IHT

Exp. duration:

8 h

Remarks on result:

other: 0/12 animals died after 8 hour of exposure to the test atmosphere. Due to the design of atmosphere generation, no exposure to the test substance is to exspected.

Mortality:

0/12 animals died

Clinical signs:

other: No symptoms were observed.

Gross pathology:

No findings were reported.

Any other information on results incl. tables

Due to the design of atmosphere generation, no exposure to the test substance is to exspected.