Registration Dossier
Registration Dossier
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EC number: 943-359-7 | CAS number: 2149581-44-0
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study with detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- MAEEBP
- IUPAC Name:
- MAEEBP
- Reference substance name:
- 2-[2-(4-benzoylphenoxy)ethoxy]ethyl 2-methylprop-2-enoate
- EC Number:
- 943-359-7
- Cas Number:
- 2149581-44-0
- Molecular formula:
- C21H22O5
- IUPAC Name:
- 2-[2-(4-benzoylphenoxy)ethoxy]ethyl 2-methylprop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): MAEEBP- Physical state: colourless liquid- Composition of test material, percentage of components: 4-methacryloyl diethoxy benzophenone 85 area%, impurities 4-hydroxybenzophenone <5%, 4-methacryloyl benzophenone <5%, polymethacrylate <5%- Lot/batch No.: 150301- Expiration date of the lot/batch: Sep. 2015- Storage condition of test material: The test item was stored in the test facility in a closed vessel in the refrigerator (2-8°C) protected from light and humidity (exception: 22.- 28. Apr. 2015 storage at room temperature).
Constituent 1
Constituent 2
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 2.707
- Temp.:
- 25 °C
- Remarks on result:
- other: Peak 1
- Type:
- log Pow
- Partition coefficient:
- 3.708
- Temp.:
- 25 °C
- Remarks on result:
- other: Peak 2
Any other information on results incl. tables
The QSAR software program KOWWIN 1.68 (US EPA 2012 Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10. United States Environmental Protection Agency, Washington, DC, USA) gave an estimated log POW of 3.89.
Result of HPLC determination:
As peak 1 showed a relative area 5 %, this peak was considered as minor peak. Although area is not necessarily correlated to absolute concentration if a UV detector is used, it is assumed that the test item consists mainly of peak 2. Using the correlation log K / log POW, the log POW of the major component of test item MAEEBP was calculated as 3.708 ± 0.001 (mean ± standard deviation).
Applicant's summary and conclusion
- Conclusions:
- The log POW of MAEEBP was determined using the HPLC method according to OECD 117 resp. EU A.8. The partitioning coefficient for the major component of test item MAEEBP was calculated as 3.708.
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