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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 July - 01 October 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
- Batch n°: A14JB3422
- Analytical purity: 93.3%
- Expiration date: 30 September 2016
- Storage condition: at room temperature
Key result
Water solubility:
0.194 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.4
Details on results:
Preliminary test
The content of test item dissolved in the water sample was 0.196 g/L. Since the water solubility of the test item was >= 10^(-2) g/L, the flask method was chosen for the main study.

Main test
The results for the samples taken at 24, 48 and 72 hours are given in the table in the next section. The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analysed concentrations.
No test item was detected in the pretreated sample from the blank water mixture.

Results for the samples taken at 24, 48 and 72 hours are given in the table underneath.

 Stirring time (hours) Analysed concentration (g/L)   Mean (g/L)  Maximum Difference (MD) (%)  pH
 24  0.197 0.194  2.6  6.4
 48  0.193      6.4
 72  0.192      6.4
Conclusions:
The flask method was applied for the determination of the water solubility of JNJ-119717-AAA (T001036).
The water solubility of the test item at 20°C was 0.194 g/L. The pH of the aqueous samples was 6.4.

Description of key information

The water solubility of T001036 was determined to be 0.194 g/L at 20°C in a GLP study performed according to OECD Guideline 105, EU Method A.6 and EPA OPPTS 830.7840 (Klimisch 1, WIL Research Europe, 2016).

Key value for chemical safety assessment

Water solubility:
0.194 g/L
at the temperature of:
20 °C

Additional information

Next to the key study (Klimisch 1, WIL Research Europe, 2016), reporting a water solubility of 0.194 g/L, a Klimisch 4 study is available (experiment performed at Janssen Pharmaceutica), reporting a water solubility of 0.210 g/L. This study can be considered as supporting information.