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EC number: 272-275-7
CAS number: 68784-82-7
Using a theoretical approach and the available physico-chemical properties and toxicological data, the following absorption factors were derived for risk assessment purposes: oral absorption factor: 10%; dermal absorption factor: 10%; inhalation absorption factor: 100%
L579 is considered to be insoluble in
water. In general a substance needs to be dissolved before it can be
taken up from the gastro-intestinal tract. Thus, the water insolubility
can be considered a potentially rate-limiting factor for the absorption
of the compound. The low molecular weight of this substance is
favourable for absorption. After oral administration, it is unlikely
that L579 will show a high systemic exposure. In the presence of food
and bile salts some systemic exposure might be possible. For risk
assessment purposes the oral absorption of L579 is set at 10% as a worst
Once absorbed, distribution of L579
throughout the body will be limited due to its water insolubility.
Based on the particle size of L579
(98.21% < 10 μm), particles < 100 μm
which have a potential to be inhaled, are present. Particles with an
aerodynamic diameter below 50 μm may reach the
thoracic regions, whereas particles with an aerodynamic diameter below
15 μm may reach the alveolar region of the respiratory
tract. The water insolubility of L579 indicates that L579 will not
dissolve into the mucus lining of the respiratory tract and the deposits
in the nasopharyngeal region will likely to be coughed or sneezed out of
the body, or swallowed. As most of the particles have a size < 10 μm
(98.21%), the fraction that will reach the alveolar region of the
respiratory tract will be available for absorption. For risk assessment
purposes the inhalation absorption of L579 is set at 100%.
L579 being a solid which is considered
to be insoluble in water has no real potential for dermal absorption.
Its molecular weight above 100 does not favour dermal absorption. Based
on these physical/chemical properties of L579, dermal absorption is
considered to be low. Although the criteria for 10% dermal absorption as
given in the REACH guidance (Guidance for the implementation of REACH.
Guidance on information requirements and chemical safety assessment.
Chapter R.7c: Endpoint specific guidance. European Chemical Agency, May
2008) (MW > 500 and log Pow < -1 or > 4) are not met as data on log Pow
are not available for inorganic substances, 100% dermal absorption is
considered not relevant for L579 as it is generally accepted that dermal
absorption does not exceed oral absorption. For risk assessment purposes
therefore, 10% dermal absorption of L579 as default value is considered
to be appropriate.
Based on the present available data,
no additional conclusions can be drawn on the distribution, metabolism
and excretion of L579 after absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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